Buprenorphine Metabolism in Human Liver, Human Placenta, and Recombinant Cyp19 Microsomes
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چکیده
منابع مشابه
Metabolism of phencyclidine by human liver microsomes.
These studies examined in vitro metabolism of phencyclidine (PCP) in a series of human liver microsomes (N = 10). Each sample was characterized for cytochrome P450 (CYP) content and for CYP1A, CYP2A, CYP2C, CYP2D, CYP2E, CYP3A, CYP4A, and lauric acid 11-hydroxylation metabolic activities. At least five PCP metabolites (c-PPC, t-PPC, PCHP, an unknown metabolite, and an irreversibly bound metabol...
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beta-Arteether (AE) is an endoperoxide sesquiterpene lactone derivative currently being developed for the treatment of severe, complicated malaria caused by multidrug-resistant Plasmodium falciparum. Studies were undertaken to determine which form(s) of human cytochrome P-450 catalyze the conversion of beta-arteether to its deethylated metabolite, dihydroqinghaosu (DQHS), itself a potent antima...
متن کاملMETABOLISM OF b-ARTEETHER TO DIHYDROQINGHAOSU BY HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450
b-Arteether (AE) is an endoperoxide sesquiterpene lactone derivative currently being developed for the treatment of severe, complicated malaria caused by multidrug-resistant Plasmodium falciparum. Studies were undertaken to determine which form(s) of human cytochrome P-450 catalyze the conversion of b-arteether to its deethylated metabolite, dihydroqinghaosu (DQHS), itself a potent antimalarial...
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ژورنال
عنوان ژورنال: Proceedings of IMPRS
سال: 2019
ISSN: 2641-2470
DOI: 10.18060/23459